Mature cardiomyocytes recall their progenitor experience via polycomb repressive complex 2.
نویسندگان
چکیده
Polycomb repressive complex 2 (PRC2) deposits repressive epigenetic marks that silence inappropriate gene expression programs. Recent work from DelgadoOlguín et al1 in conjunction with studies from other laboratories2–4 show that PRC2 activity in cardiac progenitors influences growth and gene expression of mature cardiomyocytes. These studies illustrate the power of epigenetic mechanisms to retain information about the heart’s developmental history and deploy it to influence mature heart function.
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ورودعنوان ژورنال:
- Circulation research
دوره 111 2 شماره
صفحات -
تاریخ انتشار 2012